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Sudheer J. (MANJU)
A novel naphthanol glycoside from Terminalia arjuna with antioxidant
and nitric oxide inhibitory activities.
Ali A, Kaur G, Hayat K, Ali M, Ather M
Pharmazie 2003; 58:932-4.
Abstract: A novel naphthanol glycoside, arjunaphthanoloside (1), was
isolated from the stem bark of Terminalia arjuna and its structure was
established as 2,3,6,7,8,9-hexahydroxynaphthalene-2-O-alpha-L(-)-
rhamnoside by means of spectroscopic and chemical methods. Compound 1
showed potent antioxidant activity and inhibited nitric oxide (NO)
production in lipopolysaccharide (LPS)-stimulated rat peritoneal
macrophages.
MeSH: Animals; Antioxidants; Cardiotonic Agents; Free Radical
Scavengers; Glycosides; Hydrolysis; Lipopolysaccharides; Lipoproteins,
LDL; Macrophages, Peritoneal; Magnetic Resonance Spectroscopy;
Naphthalenes; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide
Synthase Type II; Picrates; Plant Bark; Plant Extracts; Rats;
Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet;
Superoxides; Terminalia
CAS Registry Number (Substance Name): 0 (Antioxidants), 0 (Cardiotonic
Agents), 0 (Free Radical Scavengers), 0 (Glycosides), 0
(Lipopolysaccharides), 0 (Lipoproteins, LDL), 0 (Naphthalenes), 0
(Picrates), 0 (Plant Extracts), 0 (arjunaphthanoloside), 10102-43-9
(Nitric Oxide), 11062-77-4 (Superoxides), 1898-66-4 (2,2-diphenyl-1-
picrylhydrazyl), EC 1.14.13.39 (Nitric Oxide Synthase), EC 1.14.13.39
(Nitric Oxide Synthase Type II), EC 1.14.13.39 (Nos2 protein, rat)
Author Address: Faculty of Pharmacy, Hamdard University, Hamdard
Nagar, New Delhi, India.
MEDLINE record details
Publication Type: In Vitro; Journal Article; Research Support, Non-
U.S. Gov't
ISSN: 0031-7144
Country: Germany
Language: eng
Date of Entry: 20040105
Unique Identifier: 14703977
Journal Subset: IM
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.14703977
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J Indian Med Assoc. 1966 Mar 1;46(5):234-7.
A study of anti-arthritic action of Vanda roxburghii in albino rats.
Prasad DN, Achari G.
PMID: 5906161 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/5906161
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ABIM - An Annotated Bibliography of Indian Medicine
A study of anti-arthritic action of Vanda roxburghii in albino rats.
Author(s): Prasad, D.N. and G. Achari
Title: A study of anti-arthritic action of Vanda roxburghii in albino
rats
Publication date: 1966
Published in: Journal of the Indian Medical Association 46, 234
Checked: no
Description: on Vanda tessellata (Roxb.) Hook. ex G.Don = Vanda
roxburghii R.Br.
________________________________________
found: 0 titles on 0 pages
_______________________________________
ID 17295
Mother ID 18
Order Prasad D N and G Achari
Name 87139
Publish yes
OAI name Publication
Path root/P/87139/
Short title NL 87139
Short title EN 87139
Created on: 2007-10-12 09:10:16
Last modified: 2010-02-28 17:33:08
Author(s) Prasad, D.N. and G. Achari
Author(s) order Prasad, D N and G Achari
Title A study of anti-arthritic action of Vanda roxburghii in albino
rats
Title order A study of anti-arthritic action of Vanda roxburghii in
albino rats
Exchangeable no
Printing on demand no
Date issued 1966
Date submitted 1966
Language en
Type Article / Letter to editor
Published in Journal of the Indian Medical Association 46, 234
Checked no
Additional info on Vanda tessellata (Roxb.) Hook. ex G.Don = Vanda
roxburghii R.Br.
Relation URI http://www.rug.nl/
Rights University of Groningen
ReferenceID 87139
http://indianmedicine.eldoc.ub.rug.nl/root/P/87139/?pFullItemRecord=ON
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A study of anti-arthritic action of Vanda roxburghii in albino rats.
Prasad DN, Achari G
J Indian Med Assoc 1966; 46:234-7.
MeSH: Animals; Arthritis; Glycosides; Male; Medicine, Ayurvedic;
Plants, Medicinal; Prednisolone; Rats
CAS Registry Number (Substance Name)
0 (Glycosides), 50-24-8 (Prednisolone)
MEDLINE record details
Publication Type: Comparative Study; In Vitro; Journal Article
ISSN: 0019-5847
Country: INDIA
Language: eng
Date of Entry: 19660522
Unique Identifier: 5906161
Journal Subset: IM
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.5906161?articleTitle=[Pharmacological+study+on+Arctostaphylos+uva-ursi+%28L.%29+Spreng.+II.+Combined+effects+of+arbutin+and+prednisolone+or+dexamethazone+on+immuno-inflammation]&citedBy=false&medlinePmidWithoutMDLNPrefix=2355310&related=true&searchDisciplineField=all&search_area=medline&search_currenturl=http%3A%2F%2Fwww.ophsource.org%2Fperiodicals%2Fophtha%2Fmedline%2Frelated%2FMDLN.2355310&search_dateradio=combo&search_federated=no&search_hits=123799&search_medline=yes&search_preview=no&search_query=Related+to%3A+[Pharmacological+study+on+Arctostaphylos+uva-ursi+%28L.%29+Spreng.+II.+Combined+effects+of+arbutin+and+prednisolone+or+dexamethazone+on+immuno-inflammation]&search_reqcount=20&search_reqfirst=1&search_sort=relevance&search_source=MEDLINE&search_wordsexactly=yes&select1=relevance&select1=relevance&select3=20&select3=20
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J Indian Med Assoc. 1966 Mar 1;46(5):234-7.
A study of anti-arthritic action of Vanda roxburghii in albino rats.
Prasad DN, Achari G.
PMID: 5906161 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/5906161
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A study of anti-arthritic action of Vanda roxburghii in albino rats.
http://www.ophsource.org/periodicals/ophtha/medline/record/MDLN.5906161
Prasad DN, Achari G
J Indian Med Assoc 1966; 46:234-7.
MeSH: Animals; Arthritis; Glycosides; Male; Medicine, Ayurvedic;
Plants, Medicinal; Prednisolone; Rats
CAS Registry Number (Substance Name)
0 (Glycosides), 50-24-8 (Prednisolone)
MEDLINE record details
Publication Type: Comparative Study; In Vitro; Journal Article
ISSN: 0019-5847
Country: INDIA
Language: eng
Date of Entry: 19660522
Unique Identifier: 5906161
Journal Subset: IM
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Methods Find Exp Clin Pharmacol. 2005 Nov;27(9):633-8.
Antilithiatic effect of Asparagus racemosus Willd on ethylene glycol-
induced lithiasis in male albino Wistar rats.
Christina AJ, Ashok K, Packialakshmi M, Tobin GC, Preethi J, Murugesh
N.
The ethanolic extract of Asparagus racemosus Willd. was evaluated for
its inhibitory potential on lithiasis (stone formation), induced by
oral administration of 0.75% ethylene glycolated water to adult male
albino Wistar rats for 28 days. The ionic chemistry of urine was
altered by ethylene glycol, which elevated the urinary concentration
of crucial ions viz. calcium, oxalate, and phosphate, thereby
contributing to renal stone formation. The ethanolic extract, however,
significantly (p < 0.05) reduced the elevated level of these ions in
urine. Also, it elevated the urinary concentration of magnesium, which
is considered as one of the inhibitors of crystallization. The high
serum creatinine level observed in ethylene glycol-treated rats was
also reduced, following treatment with the extract. The
histopathological findings also showed signs of improvement after
treatment with the extract. All these observations provided the basis
for the conclusion that this plant extract inhibits stone formation
induced by ethylene glycol treatment.
PMID: 16357948 [PubMed - indexed for MEDLINE]
Publisher: Prous
Identify: ISSN: 0379-0355
Source: Methods and findings in experimental and clinical pharmacology
Y. 2005, vol. 27, No. 9, pages 633-638 [6 pages] [bibl. 32 ref.]
Language: English
http://cat.inist.fr/?aModele=afficheN&cpsidt=17338773
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Methods and Findings
Methods Find Exp Clin Pharmacol 2005, 27(9): 633
ISSN 0379-0355
Copyright 2005 Prous Science
CCC: 0379-0355
DOI: 10.1358/mf.2005.27.9.939338
Antilithiatic effect of Asparagus racemosus willd on ethylene glycol
induced lithiasis in male albino Wistar rats
Christina, A.J.M.
The ethanolic extract of Asparagus racemosus Willd. was evaluated for
its inhibitory potential on lithiasis (stone formation), induced by
oral administration of 0.75% ethylene glycolated water to adult male
albino Wistar rats for 28 days. The ionic chemistry of urine was
altered by ethylene glycol, which elevated the urinary concentration
of crucial ions viz. calcium, oxalate, and phosphate, thereby
contributing to renal stone formation. The ethanolic extract, however,
significantly (p < 0.05) reduced the elevated level of these ions in
urine. Also, it elevated the urinary concentration of magnesium, which
is considered as one of the inhibitors of crystallization. The high
serum creatinine level observed in ethylene glycol-treated rats was
also reduced, following treatment with the extract. The
histopathological findings also showed signs of improvement after
treatment with the extract. All these observations provided the basis
for the conclusion that this plant extract inhibits stone formation
induced by ethylene glycol treatment.
Full Text: HTML, PDF
http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=6&p_RefId=939338&p_IsPs=N
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Title: Antioxidant and hypocholesterolaemic effects of Terminalia
arjuna tree-bark powder: a randomised placebo-controlled trial.
Author: Gupta, R : Singhal, S : Goyle, A : Sharma, V N
Citation: J-Assoc-Physicians-India. 2001 Feb; 49231-5
Abstract: OBJECTIVE: To evaluate the antioxidant and
hypocholesterolaemic effects of Terminalia arjuna tree bark (a popular
cardiotonic substance in Indian pharmacopoeia) and to compare it with
a known antioxidant, vitamin E, we performed a randomized controlled
trial. METHODS: One hundred and five successive patients with coronary
heart disease (CHD) presenting to our centre were recruited and using
a Latin-square design divided into 3 groups of 35 each. The groups
were matched for age, lifestyle and dietary variables, clinical
diagnosis and drug treatment status. None of the patients was on lipid-
lowering drugs. Supplemental vitamins were stopped for one month
before study began and American Heart Association Step II dietary
advice was given to all. At baseline, total cholesterol,
triglycerides, HDL and LDL cholesterol and lipid peroxide estimated as
thiobarbituric acid reactive substances (TBARS) were determined. Group
I received placebo capsules; Group II vitamin E capsules 400 units/
day; and Group III received finely pulverized T. arjuna tree bark-
powder (500 mg) in capsules daily. Lipids and lipid peroxide levels
were determined at 30 days follow-up. RESULTS: Response rate in
various groups varied from 86% to 91%. No significant changes in
total, HDL, LDL cholesterol and triglycerides levels were seen in
Groups I and II (paired t-test p greater than 0.05). In Group III
there was a significant decrease in total cholesterol (-9.7 +/-
12.7%), and LDL cholesterol (-15.8 +/- 25.6%) (paired t-test p less
than 0.01). Lipid peroxide levels decreased significantly in both the
treatment groups (p less than 0.01). This decrease was more in vitamin
E group (-36.4 +/- 17.7%) as compared to the T. arjuna group (-29.3
+/- 18.9%). CONCLUSIONS: Terminalia arjuna tree bark powder has
significant antioxidant action that is comparable to vitamin E. In
addition, it also has a significant hypocholesterolaemic effect.
Review References: None
Notes: None
Language: English
Publication Type: Clinical-Trial; Journal-Article; Randomized-
Controlled-Trial
Keywords: Anticholesteremic Agents therapeutic use : Antioxidants
therapeutic use : Hyperlipidemia drug therapy : Plants, Medicinal
therapeutic use : Vitamin E therapeutic use.
URL: No URL associated with this record.
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=163390
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Cardio-protective role of Terminalia arjuna bark extract is possibly
mediated through alterations in thyroid hormones
Author(s): H. S. Parmar 1, | S. Panda 2, | R. Jatwa 3, | A. Kar 4 *
Pharmazie Print ISSN: 0031-7144 | Electronic ISSN: 0031-7144
Volume: 61 | Issue: 9 Cover date: September 2006 Page(s): 793-795
Abstract: Terminalia arjuna bark extract is believed to exhibit cardio-
protective effects. In the present study we investigated the possible
involvement of thyroid hormones in the amelioration of cardiac and
hepatic lipid peroxidation (LPO) by a bark extract of the plant in
albino rats. While l-thyroxine (l-T4) treatment increased the level of
thyroid hormones, heart/body weight ratio as well as cardiac and
hepatic lipid peroxidation, simultaneous administration of 21.42 and
42.84 mg/kg of the plant extract decreased the level of thyroid
hormones and also the cardiac LPO, suggesting the possible mediation
of the drug action through an inhibition in thyroid function. These
effects were comparable to a standard antithyroid drug, propyl
thiouracil (PTU). When the drug was administered to euthyroid animals,
serum concentrations of thyroid hormones were decreased, whereas the
hepatic LPO increased indicating a drug induced toxicity in euthyroid
subjects. Although a suboptimal dose of the drug was found to be
nontoxic to the liver, it appeared to be of no use, as it could
neither affect the thyroid functions nor the cardiac lipid
peroxidation. Since in euthyroid animals, thyroid hormones were
decreased and hepatic LPO was increased, it is suggested that high
amounts of this plant extract should not be consumed, as
hepatotoxicity as well as hypothyroidism may be caused.
http://www.atypon-link.com/GVR/doi/abs/10.5555/phmz.61.9.793
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Indian J Physiol Pharmacol. 1971 Jul;15(3):93-6.
Effect of Tribulus terrestris fruit extracts on chloride and
creatinine renal clearances in dogs.
Singh RC, Sisodia CS.
PMID: 5137670 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/5137670
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The Journal of Steroid Biochemistry and Molecular Biology
Volume 49, Issues 2-3, June 1994, Pages 153-160
doi:10.1016/0960-0760(94)90005-1 | How to Cite or Link Using DOI
Copyright © 1994 Published by Elsevier Ltd. Cited By in Scopus (215)
Permissions & Reprints
Interaction of naturally occurring nonsteroidal estrogens with
expressed recombinant human estrogen receptor
Richard J. Miksiceka
Abstract: The interaction between the recombinant human estrogen
receptor and a variety of nonsteroidal estrogens was studied using a
transient transfection assay in mammalian cells. Eight naturally
occurring compounds were confirmed to stimulate the transcriptional
activity of the human estrogen receptor and to compete for the binding
of radiolabeled 17β-estradiol to this protein. In order of biological
potency, these were zearalenone, β-zearalenol, coumestrol, genistein,
daidzein, phloretin, formononetin, and biochanin A. As with steroidal
estrogens, the hormonal activity of these compounds was specific for
the estrogen receptor and sensitive to inhibition by 4-
hydroxytamoxifen and ICI-164,384. Evidence is also presented to
indicate that the stimulatory activity of genistein is unrelated to
the protein tyrosine kinase inhibitory activity of this isoflavone.
These results demonstrate that a significant number of structurally
diverse plant and fungal secondary metabolites exist in nature that
may contribute to the total estrogen exposure of the human population.
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Journal of Ethnopharmacology
Volume 4, Issue 2, September 1981, Pages 229-232
doi:10.1016/0378-8741(81)90037-4 | How to Cite or Link Using DOI
Copyright © 1981 Published by Elsevier Ireland Ltd. Cited By in
Scopus (40)
Permissions & Reprints
Short communication
Scientific evidence on the role of Ayurvedic herbals on
bioavailability of drugs
C.K. Atala, Usha Zutshia and P.G. Raoa
aRegional Research Laboratory, Jammu-Tawi J&K, India
Received 7 March 1980;
Revised 14 August 1980.
Available online 6 November 2002.
Abstract: Experiments were conducted to evaluate the scientific basis
of the use of the trikatu group of acrids (long pepper, black pepper
and ginger) in the large number of prescriptions in Ayurveda. [3H]
vasicine and [3H] sparteine were taken as test drugs. Piper longum
(long pepper) increased the blood levels of vasicine by nearly 233%.
Under the influence of piperine, the active principle of Piper
species, sparteine blood levels increased more than 100%. The results
suggest that these acrids have the capacity to increase the
bioavailability of certain drugs. It appears that the trikatu group of
drugs increase bioavailability either by promoting rapid absorption
from the gastrointestinal tract, or by protecting the drug from being
metabolised/oxidised in its first passage through the liver after
being absorbed, or by a combination of these two mechanisms.
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